My doctor advised me to get vaccinated against the Japanese encephalitis before a trip to Cambodia. He recommended three injections in order to get protected for 10 years: a first injection, a second one a month later and a third one six months later.

I know that the basic principle of vaccination is to inject an innocuous version of a virus so that the immune system knows it, and recognizes it and respond to it quickly in case of contact with the real virus.

Could someone explain how the multiple injections vaccination works?

As a guideline for answering:

  1. Why three injections and not one as for many other vaccinations?
  2. Are the three injections in the process the same?
  3. How flexible is this schedule? In particular, I had always been confused by the "6 months later" for the third injection. Is it 6 months after the first or the second injection? Does it matter?
  • 10 years is a long time compared to 1 year tops suggested by reputable sites. Plus it's 2 doses and not 3. Look at the relevant pages on NHS and CDC – Chris Rogers Jul 5 '17 at 7:35
  • See also this journal article on clinical tests for length of cover – Chris Rogers Jul 5 '17 at 7:46

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