In the FOURIER study (to lower cholesterol with PCSK9), there is a significant reduction in different types of cardiovascular events (MI and Stroke) in the treatment group and yet the total cardiovascular mortality has not decreased compared to placebo (page 6 of pdf). What kind of other conditions/diagnoses could account for the extra deaths in the treatment group from 'Cardiovascular death' that compensates for MI and stroke?


Cardiovascular death is a general term meaning death caused by anything involving the heart or blood vessels. I can't find and don't think there exists a formal definition. Aside from stroke and MI, the major examples would be:

  • thanks, that's roughly the list I was looking for (possibly in addition to the breakdown for this specific study, but I realize that might be hard without having full study data ...).
    – Curios
    Apr 1 '17 at 23:33
  • 1
    @Curios Yeah, having the study's working definition would be the best. I only skimmed the paper so I could have missed it, but I didn't see them define it, which they really should have.
    – Carey Gregory
    Apr 2 '17 at 1:37

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