My question is applicable to all multi-dose vaccines with vaccination intervals of several weeks, though the specific case that triggered my question was the chickenpox vaccine Varilrix/GSK.
My assumption is that, if after the first dose of the chickenpox vaccine, the patient develops chickenpox-like blisters (more than 10), that seroconversion occurred and that the patient would have detectable and lasting antibodies against chickenpox.
If that is true and if seroconversion certainly happened, is it at all necessary to vaccinate a second time?
My analogy is that, if actual chickenpox infection conveys long lasting immunity and the vaccine-strain infection certainly happened, will that be enough for long-lasting immunity?
Or is vaccine effectiveness independent of how the immune system reacts to a single dose?